2025
Pigors M, Goletz S, Wang Y, Emtenani S, Hammers CM, Holtsche MM, Patzelt S, Opelka B, Stang FH, König IR, Radzimski C, Komorowski L, Aumailley M, Has C, Schmidt E. Anti-Laminin β4 IgG Drives Tissue Damage in Anti-p200 Pemphigoid and Shows Interactions with Laminin α3 and γ1/2 Chains. J Invest Dermatol. 2025 Apr;145(4):821-830.e3. doi: 10.1016/j.jid.2024.08.004.
Stenger S, Vorobyev A, Bieber K, Lange T, Ludwig RJ., Hundt JE. Insomnia Increases the Risk for Specific Autoimmune Diseases: A Large-Scale Retrospective Cohort Study. Front Netw Physiol. 2025 Apr 10:5:1499297. doi: 10.3389/fnetp.2025.1499297.
Hartmann V, Guo S, Rahimi S, Radine U, Malheiros D, Salviano-Silva A, Bumiller-Bini Hoch V, Cipolla GA, Calonga-Solis V, Künstner A, Burmester I, Ludwig RJ, Hariton WVJ, Hammers CM, Müller EJ, Busch H, Hundt JE. In pemphigus, cell detachment, but not autoantibody binding, induces cell-wide, long-lasting transcriptomic and proteomic changes bioRxiv 2025.02.10.637416. 2025. doi: 0.1101/2025.02.10.637416
Kridin K, Papara C, Bieber K, De Luca DA, Klein JP, Ludwig MA, Curman P, Vorobyev A, Dempfle A, Ludwig RJ. Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study. Front Psychiatry. 2025 Feb 12;16:1429297. doi: 10.3389/fpsyt.2025.1429297.
Mousavi S, Bieber K, Zirpel H, Vorobyev A, Olbrich H, Papara C, De Luca DA, Thaci D, Schmidt E, Riemekasten G, Lamprecht P, Laudes M, Kridin K, Ludwig RJ. Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatory diseases. Front Endocrinol (Lausanne). 2025 Feb 3;16:1516433. doi: 10.3389/fendo.2025.1516433
Buhre JS, Pongracz T, Geisen UM, Schubert M, Wang W, Nouta J, Obara M, Lehrian S, Rahmöller J, Petry J, Tran F, Schreiber S, Sümbül M, Berner D, Gerdes S, Schirmer J, Longardt AC, Hoff P, Kalinke U, Ludwig RJ, Bartsch YC, Hoyer BF, Wuhrer M, Ehlers M. Anti-TNF therapy impairs both short- and long-term IgG responses after repeated vaccination. Allergy. 2025 Feb;80(2):423-439. doi: 10.1111/all.16241.
Rastegar Lari T, Macias L, Robrahn L, Dikmen HO, Prüßmann J, Kiehne C, Engster S, Weyers I, Szymczak S, van Beek N, Hoffmann MH, Schmidt E, Emtenani S. Localization of Lesions in Autoimmune Blistering Diseases Is Independent of Site-Specific Target Antigen Expression. Life (Basel). 2025 Jan 31;15(2):218. doi: 10.3390/life15020218.
Raudszus L, Bahreini F, Allan S, Kalies KU, Caldwell CC, Kalies K. Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity. Front Immunol. 2025 Jan 22;15:1494400. doi: 10.3389/fimmu.2024.1494400.
2024
Ohmes J, Mehrpouyan A, Wimmer-Groß J, Ahmed AR, Amber KT, Biswas S, Christiano A, Emtenani S, Goletz S, Hundt JE, Kirchhoff L, Kridin K, Lasselin J, Laudes M, Lee WY, Ludwig RJ, Murthy S, Mousavi S, Nemeth T, Neumann M, Popken I, Saurabh R, Sbaraglia AM, Schanzenbacher J, Schmidt C, Schmidt-Jimènez LF, Scheiner CW, Schlotfeldt M, Schoell N, Bahreini F, Stenger S. Meeting Report on "The International Congress on Autoimmune Pre-disease (2024)". JID Innov. 2024 Dec 18;5(3):100342. doi: 10.1016/j.xjidi.2024.100342.
Saurabh R, Cani A, Möller M, Busch H. Large-scale global retrospective study on the interaction between ancestry and risk of comorbid autoimmune diseases in patients with pemphigus. Sci Rep. 2024 Dec 3;14(1):30151. doi: 10.1038/s41598-024-78031-z.
Zheng J, Guo J, Wang G, Zhang L, Yu X, Liu D, Lin Y, Zhang R, Ma A, Yu X. Interstitial lung abnormality in COPD is inversely associated with the comorbidity of lung cancer. BMC Pulm Med. 2024 Oct 10;24(1):506. doi: 10.1186/s12890-024-03311-3
Tegtmeyer J, Romagnuolo M, Hammers CM, Opelka B, Probst C, Komorowski L, Marzano AV, Schmidt E, Goletz S. Reactivity against the BP180 ectodomain in patients with bullous pemphigoid, mucous membrane pemphigoid, multiple sclerosis and Parkinson disease. Exp Dermatol. 2024 Jul;33(7):e15125. doi: 10.1111/exd.15125.
Gross N, Marketon J, Mousavi S, Kalies K, Ludwig RJ, Bieber K. Inhibition of interferon gamma impairs induction of experimental epidermolysis bullosa acquisita. Front Immunol. 2024 May 10;15:1343299. doi: 10.3389/fimmu.2024.1343299.
Liu F, Ryan ST, Fahnoe KC, Morgan JG, Cheung AE, Storek MJ, Best A, Chen HA, Locatelli M, Xu S, Schmidt E, Schmidt-Jiménez LF, Bieber K, Henderson JM, Lian CG, Verschoor A, Ludwig RJ, Benigni A, Remuzzi G, Salant DJ, Kalled SL, Thurman JM, Holers VM, Violette SM, Wawersik S. C3d-Targeted factor H inhibits tissue complement in disease models and reduces glomerular injury without affecting circulating complement. Mol Ther. 2024 Apr 3;32(4):1061-1079. doi: 10.1016/j.ymthe.2024.02.001.
2023
Rosenberger S, Undeutsch R, Akbarzadeh R, Ohmes J, Enghard P, Riemekasten G, Humrich JY. Regulatory T cells inhibit autoantigen-specific CD4+ T cell responses in lupus-prone NZB/W F1 mice. Front Immunol. 2023 Nov 10;14:1254176. doi: 10.3389/fimmu.2023.1254176
Goletz S, Pigors M, Lari TR, Hammers CM, Wang Y, Emtenani S, Aumailley M, Holtsche MM, Stang FH, Weyers I, König IR, Has C, Radzimski C, Komorowski L, Zillikens D, Schmidt E. Laminin β4 is a constituent of the cutaneous basement membrane zone and additional autoantigen of anti-p200 pemphigoid. J Am Acad Dermatol. 2024 Apr;90(4):790-797. doi: 10.1016/j.jaad.2023.11.014. Epub 2023 Nov 20
Bieber K, Bezdek S, Gupta Y, Vorobyev A, Sezin T, Gross N, Prüssmann J, Sayegh JP, Becker M, Mousavi S, Hdnah A, Künzel S, Ibrahim SM, Ludwig RJ, Gullberg D, Sadik CD. Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis. J Pathol. 2023 Oct;261(2):184-197. doi: 10.1002/path.6162.
De Luca DA, Papara C, Vorobyev A, Staiger H, Bieber K, Thaçi D, Ludwig RJ. Lichen sclerosus: The 2023 update. Front Med (Lausanne). 2023 Feb 16;10:1106318. doi: 10.3389/fmed.2023.1106318.
Hartmann V, Hariton WV, Rahimi S, Hammers CM, Ludwig RJ, Müller EJ, Hundt JE. The human skin organ culture model as an optimal complementary tool for murine pemphigus models. Lab Anim. 2023 Aug;57(4):381-395. doi: 10.1177/00236772221145647.
Shoykhet M, Dervishi O, Menauer P, Hiermaier M, Moztarzadeh S, Osterloh C, Ludwig RJ, Williams T, Gerull B, Kääb S, Clauss S, Schüttler D, Waschke J, Yeruva S. EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation. JCI Insight. 2023 Mar 22;8(6):e163763. doi: 10.1172/jci.insight.163763.
De Luca DA, Papara C, Vorobyev A, Staiger H, Bieber K, Thaçi D, Ludwig RJ. Lichen sclerosus: The 2023 update. Front Med (Lausanne). 2023 Feb 16;10:1106318. doi: 10.3389/fmed.2023.1106318.
Stenger S, Grasshoff H, Hundt JE, Lange T. Potential effects of shift work on skin autoimmune diseases. Front Immunol. 2023 Feb 14;13:1000951. doi: 10.3389/fimmu.2022.1000951.
Papara C, De Luca DA, Bieber K, Vorobyev A, Ludwig RJ. Morphea: The 2023 update. Front Med (Lausanne). 2023 Feb 13;10:1108623. doi: 10.3389/fmed.2023.1108623.
(...) Papara C, De Luca DA, Bieber K, Ludwig RJ.Risk factors and sequelae of epidermolysis bullosa acquisita: A propensity-matched global study in 1,344 patients. Front Immunol. 2023. doi: 10.3389/fimmu.2022.1103533
Dühring L., Petry J., Lilienthal G.M., Bartsch YC, Kubiak M, Pfeufer C, Lehrian S, Buhre JS, Lunding HB, Kern C, Behrends J, Walsemann T, Gädert L, Sommer C, Krüger L, Blanchard V, Dehmel S, Jappe U, Rahmöller J, Ehlers M. Sialylation of IgE reduces FcεRIα interaction and mast cell and basophil activation in vitro and increases IgE half-life in vivo. Allergy. 2023 Feb 1. doi: 10.1111/all.15665.
Buhre JS, Pongracz T, Künsting I, Lixenfeld AS, Wang W, Nouta J, Lehrian S, Schmelter F, Lunding HB, Dühring L, Kern C, Petry J, Martin EL, Föh B, Steinhaus M, von Kopylow V, Sina C, Graf T, Rahmöller J, Wuhrer M, Ehlers M. mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine. Front Immunol. 2023 Jan 12;13:1020844. doi: 10.3389/fimmu.2022.1020844.
M, Ehlers M. mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine. Front Immunol. 2023 Jan 12;13:1020844. doi: 10.3389/fimmu.2022.1020844.
Van Coillie J, Pongracz T, Rahmöller J, Chen HJ, Geyer CE, van Vught LA, Buhre JS, Šuštić T, van Osch TLJ, Steenhuis M, Hoepel W, Wang W, Lixenfeld AS, Nouta J, Keijzer S, Linty F, Visser R, Larsen MD, Martin EL, Künsting I, Lehrian S, von Kopylow V, Kern C, Lunding HB, de Winther M, van Mourik N, Rispens T, Graf T, Slim MA, Minnaar RP, Bomers MK, Sikkens JJ, Vlaar APJ, van der Schoot CE, den Dunnen J, Wuhrer M, Ehlers M, Vidarsson G; Fatebenefratelli-Sacco Infectious Diseases Physicians group; UMC COVID-19 S3/HCW study group. The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees. EBioMedicine. 2023 Jan;87:104408. doi: 10.1016/j.ebiom.2022.104408.
2022
Föh B, Buhre JS, Sina C, Ehlers M. Influence of nutrients and metabolites on the differentiation of plasma cells and implications for autoimmunity. Front Immunol. 2022 Nov 18;13:1004644. doi: 10.3389/fimmu.2022.1004644.
Niebuhr M, Bahreini F, Fähnrich A, Bomholt C, Bieber K, Schmidt E, Ibrahim S, Hammers CM, Kalies K. Analysis of T cell repertoires of CD45RO CD4 T cells in cohorts of patients with bullous pemphigoid: A pilot study. Front Immunol. 2022 Nov 15;13:1006941. doi: 10.3389/fimmu.2022.1006941.
Buhre JS, Becker M, Ehlers M. IgG subclass and Fc glycosylation shifts are linked to the transition from pre- to inflammatory autoimmune conditions. Front Immunol. 2022 Nov 3;13:1006939. doi: 10.3389/fimmu.2022.1006939.
Ohmes J, Comdühr S, Akbarzadeh R, Riemekasten G, Humrich JY. Dysregulation and chronicity of pathogenic T cell responses in the pre-diseased stage of lupus. Front Immunol. 2022 Oct 28;13:1007078. doi: 10.3389/fimmu.2022.1007078.
Brieske C, Lamprecht P, Kerstein-Staehle A. Immunogenic cell death as driver of autoimmunity in granulomatosis with polyangiitis. Front Immunol. 2022 Oct 6;13:1007092. doi: 10.3389/fimmu.2022.1007092.
Seiler DL, Kleingarn M, Kähler KH, Gruner C, Schanzenbacher J, Ehlers-Jeske E, Kenno S, Sadik CD, Schmidt E, Bieber K, Köhl J, Ludwig RJ, Karsten CM. C5aR2 Deficiency Ameliorates Inflammation in Murine Epidermolysis Bullosa Acquisita by Regulating Fcγ Receptor Expression on Neutrophils. J Invest Dermatol. 2022 Oct;142(10):2715-2723.e2. doi: 10.1016/j.jid.2021.12.029.
Ghorbanalipoor S, Emtenani S, Parker M, Kamaguchi M, Osterloh C, Pigors M, Gross N, Khil'chenko S, Kasprick A, Patzelt S, Wortmann D, Ibrahim IO, Izumi K, Goletz S, Boch K, Kalies K, Bieber K, Smith P, Schmidt E, Ludwig RJ. Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases. Front Immunol. 2022 Sep 28;13:865241. doi: 10.3389/fimmu.2022.865241. Erratum in: Front Immunol. 2022 Nov 30;13:1099535. doi: 10.3389/fimmu.2022.1099535.
Papara C, Karsten CM, Ujiie H, Schmidt E, Schmidt-Jiménez LF, Baican A, Freire PC, Izumi K, Bieber K, Peipp M, Verschoor A, Ludwig RJ, Köhl J, Zillikens D, Hammers CM. The relevance of complement in pemphigoid diseases: A critical appraisal. Front Immunol. 2022 Aug 16;13:973702. doi: 10.3389/fimmu.2022.973702.
Opelka B, Schmidt E, Goletz S. Type XVII collagen: Relevance of distinct epitopes, complement-independent effects, and association with neurological disorders in pemphigoid disorders. Front Immunol. 2022 Aug 10;13:948108. doi: 10.3389/fimmu.2022.948108.
Saurabh R, Fouodo CJK, König IR, Busch H, Wohlers I. A survey of genome-wide association studies, polygenic scores and UK Biobank highlights resources for autoimmune disease genetics. Front Immunol. 2022 Aug 5;13:972107. doi: 10.3389/fimmu.2022.972107.
Biswas S, Bieber K, Manz RA.IL-10 revisited in systemic lupus erythematosus. Front Immunol. 2022 Aug 1;13:970906. doi: 10.3389/fimmu.2022.970906.
Schanzenbacher J, Köhl J, Karsten CM. Anaphylatoxins spark the flame in early autoimmunity. Front Immunol. 2022 Jul 25;13:958392. doi: 10.3389/fimmu.2022.958392.
Bahreini F, Niebuhr M, Belde J, Westermann J, Kalies K. Protocol to Isolate Germinal Centers by Laser Microdissection. Bio Protoc. 2022 Jun 5;12(11):e4431. doi: 10.21769/BioProtoc.4431.
Pipi E, Kasprick A, Iwata H, Goletz S, Hundt JE, Sadeghi H, Schmidt-Jiménez LF, Schmidt E, Sjögren J, Zillikens D, Ludwig RJ, Collin M, Bieber K. Multiple Modes of Action Mediate the Therapeutic Effect of Intravenous IgG in Experimental Epidermolysis Bullosa Acquisita. J Invest Dermatol. 2022 Jun;142(6):1552-1564.e8. doi: 10.1016/j.jid.2021.08.448.
Bahreini F, Niebuhr M, Belde J, Bieber K, Westermann J, Kalies K. Protocol to Induce Follicular T Helper Cells, Germinal Centers, and Skin Lesions in Mouse Models for Skin Blistering Diseases. Bio Protoc. 2022 May 20;12(10):e4414. doi: 10.21769/BioProtoc.4414.
Föh B, Buhre JS, Lunding HB, Moreno-Fernandez ME, König P, Sina C, Divanovic S, Ehlers M. Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells. PLoS One. 2022 Mar 25;17(3):e0266071. doi: 10.1371/journal.pone.0266071.
