MD A2: Anatomical expression of target antigens in autoimmune blistering dermatoses as markers for lesion formation
Autoimmune bullous dermatoses (AIBD) mainly consist of two groups. While pemphigoid diseases are characterized by autoantibodies against structural proteins of the dermalepidermal junction, pemphigus diseases are characterized by autoantibodies against the desmosomal adhesion proteins, desmoglein (Dsg) 1 and Dsg3 in the epidermis and surface-close epithelia. It is well-known that certain anatomical body regions are particularly prone to harbor lesions in specific AIBD. Blister formation in bullous pemphigoid e.g., occurs mostly on the flexural parts of the limbs, on the abdomen, and in the mucosal areas. Pemphigus diseases mostly affect mucosal areas and upper back part of the body. Yet, it has not been systematically analyzed whether these specific body regions are affected due to increased mechanical stress or high expression of the corresponding target antigens at these sites. In the present proposal, the expression of different AIBD target antigens at different body sites will be studied on the mRNA and protein levels using RT-qPCR and immunofluorescence staining in post-mortem biopsies. Result of this study will help to better understand the predilection sites of different AIBD.
- Projects
- A: Defining Autoimmune Pre-Disease
- B: Targeting of Autoimmune Pre-Disease
- Associated projects
- MD projects
- Associated MD projects
- Concluded Projects
- PhDs
- Ass. projects
- MDs
- MD A1 - Investigation of the influence of specific CDK inhibitors on neutrophil activation
- MD A2 - Conception of an anatomical expression of landscape of target antigens in autoimmune blistering dermatoses as markers for lesion formation
- MD A3 - Structural characterization of skin-directed autoantibodies and their interaction with the antigen to gain insights into autoimmune pre-disease
- MD A4 - Do interactions between AT1R autoantibodies derived from patients with systemic sclerosis and endothelial cells lead to endothelial dysfunction?
- MD A5 - Optimization and exploitation of a 3D model of human skin for translational use
- MD A6- To study vasculopathy in systemic sclerosis
- MD A7- Identification of autoantibodies contributing to the break of immunotolerance in immunization induced MMP mouse model
- MD A8- The role of AT1R antibodies and extracellular vesicles in mediating endothelial dysfunction in systemic sclerosis with pulmonary arterial hypertension
- MD A9- Impact of glycosylation on IgG4-induced signaling in neutrophils
- MD A10- Testing a new single chain variable fragment for pemphigus foliaceus in the human skin organ culture model
- MD A11- Impact of glycosylation on IgG3-induced signaling in neutrophiles
- MD A12- Screening for inhibitors to prevent keratinocytes dissoziation
- MD A13- Investigation of the local and systemic complement activation in bullous pemphigoid
- MD A14 - Impact of different subclasses on immune complex-induced signaling in neutrophils.
- MD A15 - Novel target antigens as inducers of autoimmunity of autoimmune bullous dermatoses
- MD A16 - Identification of the major epitope of the BP180 ectodomain recognized by serum IgA autoantibodies of patients with pemphigoid diseases –IgA autoantibodies as prognostic marker?
- MD A19 - Role of Staphylococcus aureus on immunogenic cell death induction in autoimmune vasculitis
- MD B1 - Testing the effect of kinase inhibitors in the human skin organ culture model
- MD B2 - Cigarette smoking-induced autoantibodies
- MD B3 - Contribution of taurine, hypoxanthine, vitamin B5 and B6 in the pathomechanism of pemphigus vulgaris
- MD B5 - Molecular characterization of the pre-autoimmune effects of Western diet in healthy mice
- Ass MDs